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Polynucleotides vs Profhilo: What’s the Difference?
Polynucleotides and Profhilo are two of the most talked-about injectable treatments for improving skin quality right now. They’re often mentioned in the same conversations and, as a result, frequently confused with one another.
However, while both treatments are designed to enhance skin health, they work in very different ways. Understanding that difference is important, because choosing the wrong treatment simply won’t deliver the results you’re hoping for.
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Profhilo: Hydration-Driven Bio-Remodelling
Profhilo is a high-concentration hyaluronic acid treatment designed to improve hydration while also stimulating collagen and elastin production within the skin.
Unlike traditional dermal fillers, Profhilo isn’t used to create volume or reshape the face. Instead, it spreads beneath the skin to improve overall skin quality. By delivering a highly purified form of hyaluronic acid that disperses through the tissue, Profhilo helps to:
- Restore hydration
- Improve elasticity
- Address early skin laxity
- Enhance overall luminosity
For patients beginning to notice subtle changes in firmness, texture or hydration, Profhilo can provide a natural improvement in skin glow and resilience without altering facial structure.
For many people, it’s an ideal early intervention treatment, supporting the skin as it begins to show the first signs of ageing.
Polynucleotides: Regeneration and Tissue Repair
Polynucleotides are a different type of bio-stimulator. Rather than focusing primarily on hydration, they are considered regenerative treatments that support tissue repair and cellular renewal.
Derived from highly purified DNA fragments, polynucleotides stimulate the skin’s natural repair processes and help improve the health and function of the tissue over time.
They are often recommended when skin requires structural support, particularly in areas where skin quality has become compromised. This may include:
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Crepey or thinning skin
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Fine lines and textural changes
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Areas with reduced skin quality
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Delicate zones such as the under-eye area
The overall aim of polynucleotides is to stimulate the skin's own repair process, to encourage healthier, more resilient tissue.
The Difference Between Profhilo and Polynucleotides
The simplest way to look at it is this: Profhilo focuses on hydration and skin remodelling, while polynucleotides focus on regeneration and repair.
Profhilo works well when skin is beginning to feel a little less firm, slightly dull or dehydrated. It improves overall skin quality by deeply hydrating the tissue and encouraging collagen and elastin production.
Polynucleotides tend to be used when the concern is more about skin condition and texture, particularly when the skin is fragile, crepey or showing signs that it needs structural support.
Which Injectable Is Right for You?
The right treatment tends to be determined in clinic, during your consultation. Two patients of the same age may require completely different approaches depending on their skin quality, genetics, lifestyle and treatment history.
At Dr. David Jack’s clinics, every recommendation is based on a detailed consultation and an honest assessment of what will deliver the best outcome.
If you’ve been researching Profhilo vs polynucleotides and aren’t sure which one you actually need, a consultation is the best place to start.
